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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RAPGEF4 All Species: 27.27
Human Site: S27 Identified Species: 50
UniProt: Q8WZA2 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WZA2 NP_001093867.1 1011 115522 S27 D K R P L E R S S E D V D I I
Chimpanzee Pan troglodytes XP_522596 881 99309
Rhesus Macaque Macaca mulatta XP_001086678 1077 122312 S93 Q Q R P L E R S S E D V D I I
Dog Lupus familis XP_545524 1011 115217 S27 V K R P L E R S S E D V D I I
Cat Felis silvestris
Mouse Mus musculus Q9EQZ6 1011 115473 S27 D K R P L E R S S E D V D I I
Rat Rattus norvegicus Q9Z1C7 436 50098
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514742 1011 115505 S27 D K R P L E R S S E D V D I I
Chicken Gallus gallus XP_426579 1011 115518 S27 D K R P L E R S S E D V D I I
Frog Xenopus laevis NP_001089076 890 102453
Zebra Danio Brachydanio rerio XP_687578 1006 115354 S28 D K R P E E R S G E D V D I I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097202 998 112889 C27 L R R V E P L C R L P G S A L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34578 1234 141798 S68 S P P A L S R S Q P P L L Q R
Sea Urchin Strong. purpuratus XP_784278 676 77986
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.3 90.8 97.8 N.A. 97.3 41.3 N.A. 93.9 92.1 45.4 78.6 N.A. 49 N.A. 31.6 39.6
Protein Similarity: 100 61 91.5 98.9 N.A. 98.6 42 N.A. 97.7 96.7 62.2 89.5 N.A. 67 N.A. 50 51.4
P-Site Identity: 100 0 86.6 93.3 N.A. 100 0 N.A. 100 100 0 86.6 N.A. 6.6 N.A. 20 0
P-Site Similarity: 100 0 93.3 93.3 N.A. 100 0 N.A. 100 100 0 86.6 N.A. 20 N.A. 26.6 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 39 0 0 0 0 0 0 0 0 0 54 0 54 0 0 % D
% Glu: 0 0 0 0 16 54 0 0 0 54 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 54 54 % I
% Lys: 0 47 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 0 0 0 54 0 8 0 0 8 0 8 8 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 8 54 0 8 0 0 0 8 16 0 0 0 0 % P
% Gln: 8 8 0 0 0 0 0 0 8 0 0 0 0 8 0 % Q
% Arg: 0 8 62 0 0 0 62 0 8 0 0 0 0 0 8 % R
% Ser: 8 0 0 0 0 8 0 62 47 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 8 0 0 0 0 0 0 0 54 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _